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HGAL is a novel interleukin-4–inducible gene that strongly predicts survival in diffuse large B-cell lymphoma

31 Dec 2002

Abstract excerpt

We have cloned and characterized a novel human gene, HGAL (human germinal center-associated lymphoma), which predicts outcome in patients with diffuse large B-cell lymphoma (DLBCL). The HGAL gene comprises 6 exons and encodes a cytoplasmic protein of 178 amino acids that contains an immunoreceptor tyrosine-based activation motif (ITAM). It is highly expressed in germinal center (GC) lymphocytes and GC-derived...

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PMID: 12509382
DOI: 10.1182/blood-2002-06-1931

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