Article
Detection of the anti-P53 antibodies in dogs with tumors.
The Journal of veterinary medical science - 1 Nov 2002
Kanaya Noriko, Okuda Masaru, Toyama Naomi, Oikawa Tatsuo, Inokuma Hisashi, Morimoto Masahiro, Hayashi Toshiharu, Une Satoshi, Nakaichi Munekazu, Taura Yasuho, Tsujimoto Hajime, Onishi Takafumi
Abstract excerpt
To detect the anti-P53 antibodies of dogs with tumors, a GST-recombinant canine (rc) P53 fusion protein was expressed and purified. Immunoblot analysis was performed using this GST-rcP53 fusion protein as an antigen and serum samples from dogs suffering from tumors as primary antibodies. Out of 16 serum samples obtained from various tumor cases, four samples showed reaction with GST-rcP53. In contrast, serum from...
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