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Article

Cloning and characterization of a novel chromosomal drug efflux gene in Staphylococcus aureus.

Biological & pharmaceutical bulletin - 1 Dec 2002

Narui Koji, Noguchi Norihisa, Wakasugi Kazunori, Sasatsu Masanori

Abstract excerpt

A novel drug efflux gene (named sepA, staphylococcal efflux pump gene) is cloned from antiseptic-resistant mutants of Staphylococcus aureus into Escherichia coli. The sepA gene conferred the reduction of susceptibility to acriflavine and the acceleration of ethidium bromide efflux from the E. coli cells. The sepA (474 bp) encoded the protein that has four predicted transmembrane segments. These results indicate...

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Identifiers

PMID: 12499635
DOI: 10.1248/bpb.25.1533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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