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Article

Discrepancies between protease inhibitor concentrations and viral load in reservoirs and sanctuary sites in human immunodeficiency virus-infected patients.

Antimicrobial agents and chemotherapy - 1 Jan 2003

Solas Caroline, Lafeuillade Alain, Halfon Philippe, Chadapaud Stéphane, Hittinger Gilles, Lacarelle Bruno

Abstract excerpt

The variable penetration of antiretroviral drugs into sanctuary sites may contribute to the differential evolution of human immunodeficiency virus (HIV) and the emergence of drug resistance. We evaluated the penetration of indinavir, nelfinavir, and lopinavir-ritonavir (lopinavir/r) in the central nervous system, genital tract, and lymphoid tissue and assessed the correlation with residual viral replication....

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Identifiers

PMID: 12499197
DOI: 10.1128/AAC.47.1.238-243.2003
PMCID: PMC149042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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