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Article

Allele-specific genotype detection of factor V Leiden mutation from polymerase chain reaction amplicons based on label-free electrochemical genosensor.

Analytical chemistry - 1 Dec 2002

Ozkan Dilsat, Erdem Arzum, Kara Pinar, Kerman Kagan, Meric Burcu, Hassmann Jörg, Ozsoz Mehmet

Abstract excerpt

An electrochemical genosensor for the genotype detection of allele-specific factor V Leiden mutation from PCR amplicons using the intrinsic guanine signal is described. The biosensor relies on the immobilization of the 21-mer inosine-substituted oligonucleotide capture probes related to the wild-type or mutant-type amplicons, and these probes are hybridized with their complementary DNA sequences at a carbon paste...

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PMID: 12498186
DOI: 10.1021/ac0257905

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CPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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