Article
Single nucleotide polymorphisms in the XPG gene: determination of role in DNA repair and breast cancer risk.
International journal of cancer - 20 Feb 2003
Kumar Rajiv, Höglund Lotta, Zhao Chunyan, Försti Asta, Snellman Erna, Hemminki Kari
Abstract excerpt
In this study we determined the effect of single nucleotide polymorphisms in the XPG gene on DNA repair and breast cancer susceptibility. Ninety individuals, with previously studied DNA repair rate at 24 hr of 2 types of UV-specific cyclobutane pyrimidines dimers (CPDs) in skin were genotyped for XPG polymorphism at codon 1104 (exon 15 G>C; Asp > His). The repair rate of TT=C dimer was similar in both wild-type...
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