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Article

Protection of DNA during early development: adaptations and evolutionary consequences.

Evolution & development - 1 Jan 2000

Epel David

Abstract excerpt

The rapidly dividing cleavage stages of embryos do not have the typical responses to cell damage, such as induction of the heat shock response, use of mitotic checkpoints, or use of apoptosis to eliminate severely damaged cells. This could create problems with integrity of DNA, but the solution in these embryos appears to be a "be prepared" approach, in which specific adaptations are used to minimize DNA damage...

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Identifiers

PMID: 12492414
DOI: 10.1046/j.1525-142x.2003.03013.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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