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Article

The Role of PPAR‐γ/RXR‐α Heterodimers in the Regulation of Human Trophoblast Invasion

1 Nov 2002

Abstract excerpt

PPAR-gamma/RXR heterodimers play a key regulatory role in murine placental development. We report here that PPAR-gamma and RXR-alpha are highly expressed in cultured primary extravillous cytotrophoblasts (EVCT) isolated from human first-trimester placenta. Using this cell culture model, we showed that PPAR-gamma agonists inhibit EVCT invasion, whereas PPAR-gamma or pan-RXR antagonists promoted EVCT invasion by...

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PMID: 12485829
DOI: 10.1111/j.1749-6632.2002.tb04601.x

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