Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analyses.

doi:10.1212/01.wnl.0000036605.89977.d0

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Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analyses.

Neurology - 10 Dec 2002

Dauvilliers Y, Mayer G, Lecendreux M, Neidhart E, Peraita-Adrados R, Sonka K, Billiard M, Tafti M

Abstract excerpt

BACKGROUND: Kleine-Levin syndrome (KLS) is a rare disorder of unknown etiology. Pathophysiologic hypotheses include a hypothalamic dysfunction and abnormalities in the central serotonin and dopamine metabolism. Several clinical symptoms also suggest an underlying autoimmune process. OBJECTIVE: To systematically investigate patients with KLS with reference to the available hypotheses. METHODS: The authors...

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