Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant.

Oncogene - 28 Nov 2002

Delhommeau François, Thierry Antoine, Feneux Danièle, Lauret Evelyne, Leclercq Edwige, Courtier Marie Hélène, Sainteny Françoise, Vainchenker William, Bennaceur-Griscelli Annelise

Abstract excerpt

As activation of telomerase represents a key step in the malignant transformation process, experimental models to develop anti-telomerase drugs provide a rational basis for anticancer strategies. We analysed the short and long-term efficacy of a stably expressed dominant-negative mutant (DN) of the telomerase catalytic unit (hTERT) in UT-7 and U937 human leukemia cell lines by using an IRES-e-GFP retrovirus. As...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Leukemia

Share to Mutation

Share to Telomerase

Share to Telomere

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12447689
DOI: 10.1038/sj.onc.1206054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant.PMID 12447689Read ↗

Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy.Semantic proximity Read ↗

Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation.Semantic proximity Read ↗

Mechanism of dominant-negative telomerase function.Semantic proximity Read ↗

Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress–induced apoptosisSemantic proximity Read ↗

Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERTSemantic proximity Read ↗

Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cellsSemantic proximity Read ↗

Ectopic Human Telomerase Catalytic Subunit Expression Maintains Telomere Length But Is Not Sufficient for CD8+ T Lymphocyte ImmortalizationSemantic proximity Read ↗

Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNASemantic proximity Read ↗

Telomerase inhibition in RenCa, a murine tumor cell line with short telomeres, by overexpression of a dominant negative mTERT mutant, reveals fundamental differences in telomerase regulation between human and murine cells.Semantic proximity Read ↗

Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation.Semantic proximity Read ↗

Loss of the malignant phenotype of human neuroblastoma cells by a catalytically inactive dominant-negative hTERT mutant.Semantic proximity Read ↗

An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.