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Article

Lack of self-averaging in neutral evolution of proteins.

Physical review letters - 11 Nov 2002

Bastolla Ugo, Porto Markus, Roman H Eduardo, Vendruscolo Michele

Abstract excerpt

We simulate neutral evolution of proteins imposing conservation of the thermodynamic stability of the native state in the framework of an effective model of folding thermodynamics. This procedure generates evolutionary trajectories in sequence space which share two universal features for all of the examined proteins. First, the number of neutral mutations fluctuates broadly from one sequence to another, leading...

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PMID: 12443510
DOI: 10.1103/PhysRevLett.89.208101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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