Article
Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma.
Journal of the National Cancer Institute - 20 Nov 2002
Figueiredo Céu, Machado José Carlos, Pharoah Paul, Seruca Raquel, Sousa Sónia, Carvalho Ralph, Capelinha Ana Filipa, Quint Wim, Caldas Carlos, van Doorn Leen-Jan, Carneiro Fátima, Sobrinho-Simões Manuel
Abstract excerpt
BACKGROUND: Both Helicobacter pylori genotype and host genetic polymorphisms play a role in determining the clinical consequences of H. pylori infection. We investigated whether there are any combinations of bacterial and host genotypes that are particularly associated with the occurrence of gastric carcinoma. METHODS: Genotypic variations in virulence-associated genes of H. pylori vacA (s and m regions) and cagA...
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