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Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2.

Cytogenetic and genome research - 1 Jan 2002

Buchet-Poyau K, Mehenni H, Radhakrishna U, Antonarakis S E

Abstract excerpt

Pathogenic mutations in the serine/threonine kinase STK11 (alias LKB1) cause Peutz-Jeghers syndrome (PJS) in most affected individuals. However, in a considerable number of PJS-patients mutations cannot be detected in STK11 suggesting genetic heterogeneity. One PJS family without STK11 mutations (PJS07) has previously been described with significant evidence for linkage to a second potential PJS locus on...

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Source

Identifiers

PMID: 12438709
DOI: 10.1159/000066620

Genes

STK11
PRKCG
KLK10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Search for the second Peutz-Jeghers syndrome locus: exclusion of the STK13, PRKCG, KLK10, and PSCD2 genes on chromosome 19 and the STK11IP gene on chromosome 2.PMID 12438709Read ↗

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.Semantic proximity Read ↗

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