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Article

Chromogranin A-activated microglial cells induce neuronal apoptosis.

Annals of the New York Academy of Sciences - 1 Oct 2002

Ulrich Gabrielle, Ciesielski-Treska Jaroslava, Taupenot Laurent, Bader Marie-France

Abstract excerpt

Chromogranin (CgA), a protein upregulated in many neuropathologies, can induce an activated phenotype in microglial cells that leads to neuronal apoptosis. The death-signaling pathways mobilized in neurons involve the death receptor Fas, p38 MAP kinase, and mitochondrial cytochrome c. We propose...

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Identifiers

PMID: 12438183
DOI: 10.1111/j.1749-6632.2002.tb04527.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12438183-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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