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Article

Insect Cells as a Factory to Produce Adeno-Associated Virus Type 2 Vectors

29 Oct 2002

Abstract excerpt

Recombinant adeno-associated viruses (rAAV) are produced transiently in mammalian cells usually by cotransfecting two or three plasmids containing AAV genes, adenovirus helper genes, and a vector genome. Expansion and transfection of adherent cells limit the scale of rAAV production. Efficient transfection is performed with cells on solid support media such as tissue culture plates. A large animal study or a...

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PMID: 12427305
DOI: 10.1089/10430340260355347

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