Article
Vascular endothelial growth factor-induced genes in human umbilical vein endothelial cells: relative roles of KDR and Flt-1 receptors.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2002
Yang Suya, Toy Karen, Ingle Gladys, Zlot Constance, Williams P Mickey, Fuh Germaine, Li Bing, de Vos Abraham, Gerritsen Mary E
Abstract excerpt
OBJECTIVE: This study evaluated the relative roles of the vascular endothelial growth factor (VEGF) receptors KDR and Flt-1 in the mediation of altered gene expression elicited by VEGF. METHODS AND RESULTS: We used mutants of VEGF selective for the KDR and Flt-1 receptors to differentiate gene expression patterns mediated by wild-type VEGF (VEGFwt) in human umbilical vein endothelial cells. RNA was extracted from...
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