Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional inhibition of genes with severe histone h3 hypoacetylation in the coding region.

Molecular cell - 1 Oct 2002

Kristjuhan Arnold, Walker Jane, Suka Noriyuki, Grunstein Michael, Roberts Douglas, Cairns Bradley R, Svejstrup Jesper Q

Abstract excerpt

Changes in histone acetylation at promoters correlate with transcriptional activation and repression, but whether acetylation of histones in the coding region of genes is important for transcription is less clear. Here, we show that cells lacking the histone acetyltransferases Gcn5 and Elp3 have widespread and severe histone H3 hypoacetylation in chromatin. Surprisingly, severe hypoacetylation in the promoter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Acetyltransferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Histone Acetyltransferases

Share to Protein Kinases

Share to RNA Polymerase II

Share to TATA Box

Share to TATA-Box Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 12419235
DOI: 10.1016/s1097-2765(02)00647-0
PMCID: PMC9035295

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional inhibition of genes with severe histone h3 hypoacetylation in the coding region.PMID 12419235Read ↗

Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation.Semantic proximity Read ↗

Deposition of histone variant H2A.Z within gene bodies regulates responsive genes.Semantic proximity Read ↗

Regulators of cellular levels of histone acetylation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Nucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14.Semantic proximity Read ↗

In vivo functions of histone acetylation/deacetylation in Tup1p repression and Gcn5p activation.Semantic proximity Read ↗

Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus.Semantic proximity Read ↗

Methylation patterns of histone H3 Lys 4, Lys 9 and Lys 27 in transcriptionally active and inactive Arabidopsis genes and in atx1 mutants.Semantic proximity Read ↗

Histone dynamics and roles of histone acetyltransferases during cold-induced gene regulation in Arabidopsis.Semantic proximity Read ↗

Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo.Semantic proximity Read ↗

H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation.Semantic proximity Read ↗

Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs.Semantic proximity Read ↗

H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.