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Article

CD4+ T-cell clones specific for wild-type factor VIII: a molecular mechanism responsible for a higher incidence of inhibitor formation in mild/moderate hemophilia A.

Blood - 15 Feb 2003

Jacquemin Marc, Vantomme Valérie, Buhot Cécile, Lavend'homme Renaud, Burny Wivine, Demotte Nathalie, Chaux Pascal, Peerlinck Kathelijne, Vermylen Jos, Maillere Bernard, van der Bruggen Pierre, Saint-Remy Jean-Marie

Abstract excerpt

Mild/moderate hemophilia A patients carrying certain mutations in the C1 domain of factor VIII (FVIII) have a higher risk of inhibitor occurrence. To analyze the mechanisms responsible for inhibitor development in such patients, we characterized FVIII-specific CD4(+) T-cell clones derived from a mild hemophilia A patient carrying an Arg2150His substitution in the C1 domain and who presented with a high titer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12393451
DOI: 10.1182/blood-2002-05-1369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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