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Article

A missense mutation in Tbce causes progressive motor neuronopathy in mice.

Nature genetics - 1 Nov 2002

Martin Natalia, Jaubert Jean, Gounon Pierre, Salido Eduardo, Haase Georg, Szatanik Marek, Guénet Jean-Louis

Abstract excerpt

Mice that are homozygous with respect to the progressive motor neuronopathy (pmn) mutation (chromosome 13) develop a progressive caudio-cranial degeneration of their motor axons from the age of two weeks and die four to six weeks after birth. The mutation is fully penetrant, and expressivity does not depend on the genetic background. Based on its pathological features, the pmn mutation has been considered an...

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PMID: 12389029
DOI: 10.1038/ng1016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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