PIN*POINT analysis on the endogenous MnSOD promoter: specific demonstration of Sp1 binding in vivo.

Abstract excerpt

Manganese superoxide dismutase (MnSOD) is a critical antioxidant enzyme that protects against superoxide anion generated as a consequence of normal cellular respiration, as well as during the inflammatory response. By employing dimethyl sulfate in vivo footprinting, we have previously identified ten basal protein binding sites within the MnSOD promoter. On the basis of consensus sequence comparison and in vitro...

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