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Article

Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole.

Clinical pharmacology and therapeutics - 1 Oct 2002

Furuta Takahisa, Shirai Naohito, Watanabe Fumitoshi, Honda Satoru, Takeuchi Ken, Iida Takayuki, Sato Yoshihiko, Kajimura Masayoshi, Futami Hajime, Takayanagi Shigekazu, Yamada Masami, Ohashi Kyoichi, Ishizaki Takashi, Hanai Hiroyuki

Abstract excerpt

BACKGROUND AND OBJECTIVES: The acid-inhibitory effect of lansoprazole depends on differences in cytochrome P450 (CYP) 2C19 genotypes. We assessed whether therapeutic effects of lansoprazole on gastroesophageal reflux disease (GERD) depended on the CYP2C19 genotype status in relation to the grade of GERD. METHODS: A total of 65 patients with GERD (grades A-D) completed treatment with lansoprazole, by taking 30 mg...

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Identifiers

PMID: 12386647
DOI: 10.1067/mcp.2002.127637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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