Article
Genome segmentation using piecewise constant intensity models and reversible jump MCMC.
Bioinformatics (Oxford, England) - 1 Jan 2002
Salmenkivi Marko, Kere Juha, Mannila Heikki
Abstract excerpt
The existence of whole genome sequences makes it possible to search for global structure in the genome. We consider modeling the occurrence frequencies of discrete patterns (such as starting points of ORFs or other interesting phenomena) along the genome. We use piecewise constant intensity models with varying number of pieces, and show how a reversible jump Markov Chain Monte Carlo (RJMCMC) method can be used to...
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