Article
XETOR regulates the size of the proneural domain during primary neurogenesis in Xenopus laevis.
Mechanisms of development - 1 Nov 2002
Cao Ying, Zhao Hui, Grunz Horst
Abstract excerpt
The interaction between early proneural genes and lateral inhibition determines the number of primary neurons. The mechanism for regulating the size of the proneural domain, however, has not been clarified. We show here that inhibition of the function of XETOR in Xenopus, a homolog of human oncoprotein ETO/MTG8, leads to a neurogenic phenotype of expanded proneural domain without alteration in the density of...
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