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Article

Resistance to beta-lactamase inhibitor protein does not parallel resistance to clavulanic acid in TEM beta-lactamase mutants.

Antimicrobial agents and chemotherapy - 1 Nov 2002

Schroeder William A, Locke Troy R, Jensen Susan E

Abstract excerpt

In order to compare patterns of resistance to inhibition by clavulanic acid with patterns of resistance to inhibition by a beta-lactamase inhibitor protein (BLIP), R164S, R244S, and R164S/R244S mutant forms of TEM beta-lactamase were prepared by site-directed mutagenesis. When kinetic parameters were determined for these mutant and wild-type forms of TEM, the single mutants showed properties that were similar to...

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Identifiers

PMID: 12384366
DOI: 10.1128/AAC.46.11.3568-3573.2002
PMCID: PMC128715

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Resistance to beta-lactamase inhibitor protein does not parallel resistance to clavulanic acid in TEM beta-lactamase mutants.PMID 12384366Read ↗

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