Article
Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2002
Reichert Torsten E, Strauss Laura, Wagner Eva M, Gooding William, Whiteside Theresa L
Abstract excerpt
We have reported earlier that T cells found in the tumor microenvironment of head and neck cancer showed evidence of apoptosis as well as decreased expression of signaling molecules. In this prospective study, spontaneous apoptosis in tumor-infiltrating lymphocytes (TILs) and in paired circulating peripheral blood lymphocytes (PBLs) was evaluated in 28 patients with oral carcinoma and correlated with zeta-chain...
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