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Article

Estimating the sensitivity of a genetic test using gene-carrier probability estimates and its application in genetic counselling.

Journal of cancer epidemiology and prevention - 1 Jan 2002

Becher H, Chang-Claude J

Abstract excerpt

BACKGROUND: The estimation of the sensitivity of a genetic test is of practical importance. If a 'gold standard' (an exact test) is not available, an estimate of the probability of being a gene carrier may be useful for an individual. This information could be based on individual pedigree and family-history data, and a known genetic model for the disease of interest. METHODS: We develop a maximum-likelihood...

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PMID: 12369601
DOI: 10.1080/14766650252962630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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