Article
[Early atrial gene regulation of obesity-related arterial hypertension].
Archives des maladies du coeur et des vaisseaux - 1 Jan 2000
Philip-Couderc P, Smih F, Pelat M, Verwaerde P, Pathak A, Buys S, Montastruc J L, Senard J M, Rouet P
Abstract excerpt
High fat diet (HFD) induces both arterial hypertension and tachycardia in dogs. Changes in heart rate occur early and are in part due to a decrease in the parasympathetic drive to the heart secondary to down-regulation of atrial muscarinic M2 receptors (Pelat et al. Hypertension 1999; 340: 1066-72). These data suggest that HFD is able to modify genic expression at atrial level. Thus, the aim of this work was to...
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