Characteristics and outcome of patients with Philadelphia chromosome negative, <i>bcr</i>/<i>abl</i> negative chronic myelogenous leukemia

Abstract excerpt

BACKGROUND: Up to 5% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia (Ph) translocation t(9;22)(q34;q11) or a bcr/abl molecular rearrangement. Although the diagnostic criteria of this entity are still under debate, there is general agreement that patients with Ph negative, bcr/abl negative CML have a severe clinical course that is not affected significantly by current treatment...

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