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Molecular and flow cytometric characterization of the CD4 and CD8 T‐cell repertoire in patients with myelodysplastic syndrome

1 Oct 2002

Abstract excerpt

We studied 18 patients with myelodysplastic syndrome (MDS), measuring clonality and T-cell receptor Vbeta (TCRBV) expression of CD4 and CD8 T cells by polymerase chain reaction and by flow cytometric analysis of TCRBV families. The CD4 and CD8 T-cell repertoire in most MDS patients is characterized by an abnormal TCRBV-restricted expansion of T cells in CD4 and CD8 cells, and increased expression of the CD8...

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PMID: 12358908
DOI: 10.1046/j.1365-2141.2002.03802.x

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