Article
Sequence analysis of the PRKAR1A gene in sporadic somatotroph and other pituitary tumours.
Clinical endocrinology - 1 Oct 2002
Kaltsas Gregory A, Kola Blerina, Borboli Ninetta, Morris Damian G, Gueorguiev Maria, Swords Frankie M, Czirják Sándor, Kirschner Lawrence S, Stratakis Constantine A, Korbonits Márta, Grossman Ashley B
Abstract excerpt
OBJECTIVE: Carney complex (CNC) is an autosomal dominant multiple neoplasia syndrome featuring cardiac, endocrine, cutaneous and neural tumours, as well as a variety of pigmented lesions of the skin and mucosa. Pituitary GH-secreting tumours are found in approximately 10% of patients with CNC. One of the genes responsible for CNC, the PRKAR1A gene located on human chromosome 17q22-24, has recently been cloned....
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