Article
[Polymorphism in codon 72 of the p53 gene and cervico-uterine cancer risk in Mexico].
Ginecologia y obstetricia de Mexico - 1 Jul 2002
Suárez-Rincón Angel Emillo, Morán-Moguel María Cristina, Montoya-Fuentes Héctor, Gallegos-Arreola Martha Patricia, Sánchez-Corona José
Abstract excerpt
A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC. As In Mexico the CC is a health public problem, we designed this study to determinate whether the p53 codon 72...
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