Microtubules of the Mouse Testis Exhibit Differential Sensitivity to the Microtubule Disruptors Carbendazim and Colchicine

Abstract excerpt

The testicular toxicant benomyl and its metabolite, carbendazim cause reproductive damage to the rat, an early sign of which is sloughing of germ cells with associated Sertoli cell fragments. However, the sensitivity of other mammalian species to these benzimidazole compounds is not clear. In this study, the effects of carbendazim and colchicine, a known microtubule disruptor, on the mouse seminiferous epithelium...

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