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Article

Altered Distribution of Cell Cycle Transcriptional Regulators during Alzheimer Disease

1 Apr 2002

Abstract excerpt

A number of mechanisms have been proposed to contribute to the selective neuronal cell loss observed during Alzheimer disease (AD). These include the formation and accumulation of amyloid-beta (Abeta)-containing plaques, neurofibrillary tangles (NFTs), and inflammatory processes mediated by astrocytes and microglia. Neuronal responses to such insults in AD brain include increased protein levels and...

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PMID: 11939591
DOI: 10.1093/jnen/61.4.358

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