Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity.

Annals of neurology - 1 Sept 2002

Saito Yuko, Suzuki Kinuko, Nanba Eiji, Yamamoto Toshiyuki, Ohno Kousaku, Murayama Shigeo

Abstract excerpt

Niemann-Pick type C disease is a neurovisceral storage disorder. Neurofibrillary tangles similar to those in Alzheimer's disease have been reported in most juvenile/adult patients without amyloid beta protein (Abeta) deposits. Recently, we found deposits of Abeta in the form of diffuse plaques in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Apolipoprotein E4
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Glycoproteins

Share to Neurofibrillary Tangles

Share to Niemann-Pick C1 Protein

Share to Niemann-Pick Diseases

Share to Tauopathies

Source

Identifiers

PMID: 12205649
DOI: 10.1002/ana.10266

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12205649-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity.PMID 12205649Read ↗

Apolipoprotein E genotype and neurological disease onset in Niemann-Pick disease, type C1.Semantic proximity Read ↗

Role of Niemann-Pick Type C Disease Mutations in Dementia.Semantic proximity Read ↗

Niemann-Pick disease type C1 predominantly involving the frontotemporal region, with cortical and brainstem Lewy bodies: an autopsy case.Semantic proximity Read ↗

Niemann-Pick Type C 1 (NPC1) and NPC2 Gene Variability in Demented Patients with Evidence of Brain Amyloid Deposition.Semantic proximity Read ↗

Familial Alzheimer's disease associated with heterozygous NPC1 mutation.Semantic proximity Read ↗

Genome sequencing in a case of Niemann-Pick type C.Semantic proximity Read ↗

Recent advances in elucidating Niemann-Pick C disease.Semantic proximity Read ↗

Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease.Semantic proximity Read ↗

New Niemann-Pick type C1 gene mutation associated with very severe disease course and marked early cerebellar vermis atrophy.Semantic proximity Read ↗

Mutations in Niemann Pick type C gene are risk factor for Alzheimer's disease.Semantic proximity Read ↗

Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin.Semantic proximity Read ↗

Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.