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Article

Fertilization in vitro increases non-disjunction during early cleavage divisions in a mouse model system

29 Aug 2002

Abstract excerpt

BACKGROUND: We have been studying an unusual mouse-the BALB/cWt (Wt) male-in which the Y chromosome is susceptible to high rates of mitotic non-disjunction, particularly at the first two cleavage divisions. As these are the same divisions that human embryos generated through assisted reproductive technology must complete in an artificial setting, analysis of the Wt Y chromosome allows us to examine the effect of...

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PMID: 12202426
DOI: 10.1093/humrep/17.9.2362

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