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Article

Premature thelarche and granulosa cell tumors: a search for FSH receptor and G5alpha activating mutations.

Journal of pediatric endocrinology & metabolism : JPEM - 1 Jan 2002

Hannon Tamara S, King Denise Walker, Brinkman Abigail D, Steinmetz Rosemary, Davis Mary M, Eugster Erica A, Pescovitz Ora H

Abstract excerpt

Activating mutations of the Gsalpha gene are responsible for McCune-Albright syndrome and have also been identified in sporadic tumors of the pituitary and thyroid. When associated with malignancy, activating Gsalpha mutations are known as gsp-oncogenes. We hypothesized that similar activating mu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12199347

Genes

FSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12199347-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Premature thelarche and granulosa cell tumors: a search for FSH receptor and G5alpha activating mutations.PMID 12199347Read ↗

Activating Gsalpha mutations: analysis of 113 patients with signs of McCune-Albright syndrome--a European Collaborative Study.Semantic proximity Read ↗

Activating GNAS1 gene mutations in patients with premature thelarche.Semantic proximity Read ↗

No activating mutations of FSH receptor in four children with ovarian juvenile granulosa cell tumors and the association of these tumors with central precocious puberty.Semantic proximity Read ↗

Heterogeneity of activating mutations of the human luteinizing hormone receptor in male-limited precocious puberty.Semantic proximity Read ↗

GNAS mutation detection is related to disease severity in girls with McCune-Albright syndrome and precocious puberty.Semantic proximity Read ↗

Disorders of puberty: inactivating and activating molecular mutations.Semantic proximity Read ↗

Clinical and endocrine characteristics and genetic analysis of Korean children with McCune-Albright syndrome: a retrospective cohort study.Semantic proximity Read ↗

Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.Semantic proximity Read ↗

Absence of activating mutations in the hot spots of the LH receptor and Gs-alpha genes in Leydig cell tumors.Semantic proximity Read ↗

Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors.Semantic proximity Read ↗

Searching for somatic mutations in McCune–Albright syndrome: a comparative study of the peptidic nucleic acid versus the nested PCR method based on 148 DNA samplesSemantic proximity Read ↗

No evidence of somatic activating mutations on gonadotropin receptor genes in sex cord stromal tumors.Semantic proximity Read ↗

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