Article
Epithelial Ca(2+) channel (ECAC1) in autosomal dominant idiopathic hypercalciuria.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Sept 2002
Müller Dominik, Hoenderop Joost G J, Vennekens Rudi, Eggert Paul, Harangi Ferenc, Méhes Károly, Garcia-Nieto Victor, Claverie-Martin Felix, Os Carel H van, Nilius Bernd, J M Bindels René
Abstract excerpt
BACKGROUND: The epithelial Ca(2+) channel (ECaC) exhibits the defining properties for being the gatekeeper in 1,25-dihydroxyvitamin D(3)-regulated Ca(2+) (re)absorption. Its recently cloned human orthologue (ECaC1) could, therefore, represent a crucial molecule in human disorders related to Ca(2+)-wasting such as idiopathic hypercalciuria (IH). METHODS: Fifty-seven members of nine families with IH were...
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