Article
The role of vitamin D receptor gene polymorphisms in the susceptibility to prostate cancer of a southern European population.
Journal of human genetics - 1 Jan 2002
Medeiros Rui, Morais António, Vasconcelos André, Costa Sandra, Pinto Daniela, Oliveira Jorge, Lopes Carlos
Abstract excerpt
Epidemiological data indicate a relationship between ultraviolet radiation, vitamin D, and prostate cancer risk. Antiproliferative effects of vitamin D require the expression of the nuclear vitamin D receptor (VDR). A three-fold increase in prostate cancer risk associated with the less active vitamin D receptor allele (the T allele from VDR TaqI polymorphism at codon 352) was reported. The role of VDR genotypes...
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