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Article

Linkage and association analyses of the osteoprotegerin gene locus with human osteoporosis.

Journal of human genetics - 1 Jan 2002

Ohmori Hioryuki, Makita Yoshio, Funamizu Makiko, Hirooka Kenzou, Hosoi Takayuki, Orimo Hajime, Suzuki Takao, Ikari Katsunori, Nakajima Toshiaki, Inoue Ituro, Hata Akira

Abstract excerpt

Osteoprotegerin (OPG), a secreted glycoprotein and a member of the tumor necrosis factor receptor superfamily, is considered to play an important role in the regulation of bone resorption by modifying osteoclast differentiation. Overexpression of OPG in mice has been reported to result in osteopetrosis, whereas targeted disruption of OPG in mice has been associated with osteoporosis. Accordingly, OPG could be a...

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PMID: 12181640
DOI: 10.1007/s100380200058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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