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Modulation of <i>bft</i> expression by the <i>Bacteroides fragilis</i> pathogenicity island and its flanking region

1 Aug 2002

Abstract excerpt

To establish a recombinant system for high-level expression of biologically active Bacteroides fragilis toxin (BFT), we studied the expression of bft in non-toxigenic B. fragilis (NTBF) strains. The bft gene and the B. fragilis pathogenicity island (BfPAI) were cloned into NTBF strains with two distinct genetic patterns: (i) pattern II, strains lacking the BfPAI and its flanking region; and (ii) pattern III,...

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PMID: 12180925
DOI: 10.1046/j.1365-2958.2002.03077.x

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