Article
Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene.
Infection and immunity - 1 Mar 1997
Franco A A, Mundy L M, Trucksis M, Wu S, Kaper J B, Sears C L
Abstract excerpt
Strains of Bacteroides fragilis that produce a ca. 20-kDa heat-labile protein toxin (termed B. fragilis toxin [BFT]) have been associated with diarrheal disease of animals and humans. BFT alters the morphology of intestinal epithelial cells both in vitro and in vivo and stimulates secretion in ligated intestinal segments of rats, rabbits, and lambs. Previous genetic and biochemical data indicated that BFT was a...
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