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Article

Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas.

British journal of cancer - 12 Aug 2002

Barker K T, Bevan S, Wang R, Lu Y-J, Flanagan A M, Bridge J A, Fisher C, Finlayson C J, Shipley J, Houlston R S

Abstract excerpt

Germline mutations in the fumarate hydratase gene at 1q43 predispose to dominantly inherited skin and uterine leiomyomata and leiomyosarcomas. The enzyme, which is a component of the tricarboxylic acid cycle, acts as a tumour suppressor. To evaluate fumarate hydratase in respective sporadic tumours, we analysed a series of 26 leiomyosarcomas and 129 uterine leiomyomas (from 21 patients) for somatic mutations in...

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Identifiers

PMID: 12177782
DOI: 10.1038/sj.bjc.660502
PMCID: PMC2376129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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