Article
Increased plasma thrombospondin-1 (TSP-1) levels are associated with the TNF alpha-308A allele in children with juvenile dermatomyositis.
Clinical immunology (Orlando, Fla.) - 1 Jun 2002
Lutz Jennica, Huwiler Kristin G, Fedczyna Tamara, Lechman Toula S, Crawford Susan, Kinsella T Randell, Pachman Lauren M
Abstract excerpt
Vascular occlusion is more frequent in children with juvenile dermatomyositis (JDM) who have the TNF alpha-308A allele. One of the potent anti-angiogenic factors is thrombospondin-1 (TSP-1). This study investigated the association of the TNF alpha-308A allele with circulating levels of angiogenic mediators, TSP-1, and platelet factor 4 (PF4) using fresh, platelet-poor plasma (PPP). The TNF alpha-308A allele was...
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