Article
Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2002
Sunaga Noriaki, Kohno Takashi, Yanagitani Noriko, Sugimura Haruhiko, Kunitoh Hideo, Tamura Tomohide, Takei Yoshikazu, Tsuchiya Satoshi, Saito Ryusei, Yokota Jun
Abstract excerpt
Lung adenocarcinoma has replaced squamous cell lung carcinoma as the most frequent histological subtype in lung cancers. However, genetic factors that affect cancer susceptibility are much less understood in adenocarcinoma than in squamous cell carcinoma. In this study, polymorphisms in five genes involved in the metabolism of carcinogens or in the repair of damaged DNA in lung cells, NQO1-Pro187Ser,...
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