Article
The two faces of BRCA2, a FANCtastic discovery.
Molecular cell - 1 Jul 2002
Stewart Grant, Elledge Stephen J
Abstract excerpt
The molecular defects responsible for the cancer predisposition syndrome Fanconi's Anemia (FA) have been elusive. A recent study reports that the FANC-B and -D1 subgroups result from hypomorphic mutations in BRCA2. Given that BRCA2 protein participates in homologous recombination, this finding connects at least a subset of the FA phenotypes to defective DNA repair.
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