The cytosolic inclusion bodies that consist of splice variants that lack exon 5 of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients.

doi:10.1016/s0304-3940(02)00370-1

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The cytosolic inclusion bodies that consist of splice variants that lack exon 5 of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients.

Neuroscience letters - 9 Aug 2002

Manabe Takayuki, Katayama Taiichi, Sato Naoya, Kudo Takashi, Matsuzaki Shinsuke, Imaizumi Kazunori, Tohyama Masaya

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder having several pathological characteristics, namely senile plaques and neurofibrillary tangles. Further, Hirano bodies (HBs), which are stained by hematoxylin-eosin, are also observed in the AD brain. Recently, we reported that an alternative splice variant that lacked exon 5 of the presenilin-2 (PS2) gene (PS2V) was expressed in sporadic AD (SAD) brains,...

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The cytosolic inclusion bodies that consist of splice variants that lack exon 5 of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients.

Abstract excerpt

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