Article
Differential susceptibility of rats and guinea pigs to the ototoxic effects of ethyl benzene.
Neurotoxicology and teratology - 1 Jan 2000
Cappaert Natalie L M, Klis Sjaak F L, Muijser Hans, Kulig Beverly M, Ravensberg Luco C, Smoorenburg Guido F
Abstract excerpt
The present study was designed to compare the ototoxic effects of volatile ethyl benzene in guinea pigs and rats. Rats showed deteriorated auditory thresholds in the mid-frequency range, based on electrocochleography, after 550-ppm ethyl benzene (8 h/day, 5 days). Outer hair cell (OHC) loss was found in the corresponding cochlear regions. In contrast, guinea pigs showed no threshold shifts and no OHC loss after...
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