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Article

Very early-onset familial Alzheimer's disease: a novel presenilin 1 mutation.

International journal of geriatric psychiatry - 1 Jul 2002

Goldman Jill S, Reed Bruce, Gearhart Rosalie, Kramer Joel H, Miller Bruce L

Abstract excerpt

BACKGROUND: Early-onset familial Alzheimer's disease (EOFAD) is linked to mutations in three autosomal dominant genes: PS1, PS2 and APP. The clinical presentation and age of onset of mutations is variable. OBJECTIVES: The aim of this report is to describe a novel PS1 mutation believed to be causal for a very early onset of AD. METHODS: This is a case history using information from medical records, relative...

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Source

Identifiers

PMID: 12112163
DOI: 10.1002/gps.657

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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