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Transcription and replication initiate at separate sites on the vesicular stomatitis virus genome

27 Jun 2002

Abstract excerpt

The RNA-dependent RNA polymerase of the nonsegmented negative-strand RNA viruses carries out two distinct RNA synthetic processes: transcription of monocistronic, capped, and polyadenylated subgenomic messenger RNAs, and replication by means of the synthesis of a full-length positive-sense copy of the genome. The template for both processes is the negative-sense genomic RNA tightly encapsidated by the viral...

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PMID: 12089339
DOI: 10.1073/pnas.152155599

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