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Article

Association of RET codon 691 polymorphism in radiation-induced human thyroid tumours with C-cell hyperplasia in peritumoural tissue.

British journal of cancer - 17 Jun 2002

Bounacer A, Du Villard J A, Wicker R, Caillou B, Schlumberger M, Sarasin A, Suárez H G

Abstract excerpt

The RET proto-oncogene encodes a protein structurally related to transmembrane receptors with an intracellular tyrosine kinase domain. In human thyroid gland, the RET proto-oncogene is normally expressed in parafollicular C-cells. Thyroid C-cell hyperplasia is associated with inherited medullary thyroid carcinomas and is considered as a pre-neoplastic stage of C-cells disease. It has also been observed in thyroid...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12085189
DOI: 10.1038/sj.bjc.6600371
PMCID: PMC2375427

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of RET codon 691 polymorphism in radiation-induced human thyroid tumours with C-cell hyperplasia in peritumoural tissue.PMID 12085189Read ↗

High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiationSemantic proximity Read ↗

Malignant progression from C-cell hyperplasia to medullary thyroid carcinoma in 167 carriers of RET germline mutationsSemantic proximity Read ↗

[Prophylactic thyroidectomy in RET proto-oncogen mutation].Semantic proximity Read ↗

Histopathology of C Cells and Medullary Thyroid Carcinoma.Semantic proximity Read ↗

C-Cell Neoplasia in Asymptomatic Carriers of RET Mutation in Extracellular Cysteine-Rich and Intracellular Tyrosine Kinase Domain.Semantic proximity Read ↗

Histopathological and molecular studies in patients with goiter and hypercalcitoninemia: reactive or neoplastic C-cell hyperplasia?Semantic proximity Read ↗

Germline RET 634 mutation positive MEN 2A-related C-cell hyperplasias have genetic features consistent with intraepithelial neoplasia.Semantic proximity Read ↗

RET Oncogene Activation in Papillary Thyroid CarcinomaSemantic proximity Read ↗

RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults.Semantic proximity Read ↗

Normal thyroid pathology in patients undergoing thyroidectomy for finding a RETgene germline mutation: a report of three cases and review of the literature.Semantic proximity Read ↗

C-cell hyperplasia and medullary thyroid carcinoma in patients routinely screened for serum calcitonin.Semantic proximity Read ↗

Early Malignant Progression of Hereditary Medullary Thyroid CancerSemantic proximity Read ↗

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